The AC Management Successions program includes the following topics:

• Review of primary and secondary hemostasis
• Hemostasis in apheresis procedures, including how ACD-A prevents clotting in the circuit, the use of the Correct Connect AC delivery system, and the AC fluid pathways for both collections and exchanges
• AC management principles for the AC pump, AC infusion rate, and inlet:AC ratio
• How to troubleshoot clumping during an apheresis procedure by assessing the centrifuge connector and the Automated Interface Management (AIM) system images
• Steps for resolving clumping before a clot forms
• Honing skills with a review of case studies for both clumping and citrate reactions

4 to 5 hours

The Cell Collections Successions program includes the following topics:

• An overview of various cell collection targets and their therapeutic potential, including hematopoietic stem cells (HSCs) and T cells, and the sources of HSCs in the body
• Exploration of the basics of cell collections to include both mononuclear cell collection (MNC) and continuous mononuclear cell collection (CMNC) protocols
• The separation interface and how various factors influence how cells separate in the whole blood
• How to troubleshoot the Spectra Optia AIM System alarms and prevent buffy coat accumulation
• Strategies for optimizing your cell collection procedures with better troubleshooting techniques, including how to calculate collection efficiency to measure productivity
• Honing skills with a review of case studies

5 to 6 hours

The RBCX Successions program includes the following topics:

• Overview of sickle cell disease, its pathophysiology with signs and symptoms, and current treatment pathways
• Review of RBCX procedures including exchange, depletion, and depletion/exchange — including how Spectra Optia manages the hematocrit (HCT) in the patient and tubing set
• Considerations for prescribing RBCX and the clinical benefits of iron-neutral procedures
• Procedural considerations for vascular access, how to determine the appropriate fraction of cells remaining (FCR), and managing the procedure — with discussions of single-needle access
• Advancing the apheresis practice for RBCX through discussion around the ideal standard operating procedure
• Honing skills with a review of case studies using the RBCX app

6 to 7 hours

The TPE Successions program includes the following topics:

• An overview of therapeutic plasma exchange (TPE)
• Reviewing the types of devices used for TPE and the differences between these devices
• Exploring the mechanism of action of a TPE procedure
• Considerations for clinical guidelines regarding the use of TPE and what are the current treatment options
• Understanding fluid balance fluctuations and types of replacement fluids
• Exploring vascular access options when performing a TPE procedure
• Honing your skills with several case studies to apply what you have learned

6 to 7 hours