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Quantum® Cell Expansion System
Overview Videos How It Works Compare Customize Materials Cell Therapy Technologies
     

Control Your Process With an Automated Cell Culture Platform

Quantum has been proven effective in the consistent expansion of adherent cells, suspension cells, viral vectors and exosomes.



See How It Works

Discover What Quantum Can Do for You

Reduce cell harvest time

Enable Reproducible, Scalable Processes

In a study comparing MSC production in flasks versus the Quantum® Cell Expansion System, automation showed an 88% reduction in harvest time and labor hours.1


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Performance varies by user and is dependent on customer processes and materials.

Quantum system

Control Your Process

Quantum is a functionally closed, perfusion-based, automated cell expansion system that features reporting, user authentication and power failure recovery features, providing more control over the cell culture process.
Reduce Time to Manufacture

Reduce Variability Along the Cell Expansion Workflow

Use of an automated bioreactor closed system has been shown to increase yields and reduce growing times for a variety of cell types. In one publication, City of Hope generated a GMP-grade lot of clinically viable neural stem cells within nine days using Quantum, compared with six weeks using cell factories.2

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Performance varies by user and is dependent on customer processes and materials.

Reduce manufacturing open events

Exercise Flexibility

With Quantum, you can expand adherent and suspension cells and support plasmid transfections and viral transductions.
  • Suspension cells
    • T cells
    • Dendritic cells
  • Adherent cells
    • Mesenchymal stem cells (MSCs)
    • Fibroblasts
  • Viral vectors
    • HEK 293T
  • Exosomes
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Functionally closed manufacturing

Lower Risk of Contamination

Reduce open events with a closed cell culture environment.2

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Performance varies by user and is dependent on customer processes and materials.

Process Control and Protocol Flexibility

Quantum uses several predefined tasks that can be customized to replicate the manual cell culture process for a range of adherent and suspension cells. Continuous media perfusion, temperature control, cell feeding and waste removal provide process control over the cell culture environment. Operators can monitor and adjust key cell culture process parameters via the touch screen. Cells are harvested in as little as 20 minutes.

How It Works

Compact, Functionally Closed System

Maintain and customize temperature, gas control and media perfusion. The small 0.3-m2 footprint can save valuable clean room and incubator space when compared to flask-based cell expansion.
Functionally closed manufacturing

120 T-175 Flasks = One Bioreactor

The commercial bioreactor used with Quantum provides substantial surface area in minimal space. It contains about 11,500 hollow fibers with a cell culture surface area of 2.1 m2, equivalent to that of 120 T-175 flasks. This effective use of lab space results in facility, storage and workflow savings.
cell culture surface area

Maintain Cell Characteristics Consistent With Flask Culture

The National Institutes of Health (NIH) analyzed bone marrow stromal cells (BMSCs) from Quantum to determine whether they retained their differentiation potential, resulting in three major findings:
  • Cell yields in all test cases were higher when cells were grown in Quantum compared to cell factories.
  • BMSCs grown in Quantum were found to have similar phenotypes compared to BMSCs grown in cell factories.
  • BMSCs from both Quantum and cell factories can differentiate into adipocytes.
The study concluded that growth in Quantum does not alter the differentiation potential of the subset of stem cells within the BMSC population.

Direct Gas Connection: Hypoxic and Normoxic Conditions

A direct gas connection allows operators to control the cell culture environment, enabling any gas blend connection to Quantum. An internal investigation demonstrated that hypoxic and normoxic conditions make no significant difference in cell yield, viability, or phenotypic, morphological or differentiation potential.

Compare Cell Culture Flasks to Automated Cell Culture





Flasks


Labor-intensive, manual process

Quantum system
Quantum


Automated, customizable process

Possibility of variation between lab personnel and each culture

Reproducible process and a high degree of scalability

Large number of open steps through the process

Functionally closed system from cell loading through harvest

Temperature fluctuations as flasks are moved in and out of the incubator

Continuous control of temperature

Manual pipette process to feed cells and remove waste

Automated perfusion system and customizable control of cell feeding and waste removal

Cell harvest spans hours/days*

Cells harvested in as little as 20 minutes

120 T-175 flasks*

2.1 m2 (6.9 ft2) surface area

1.7 m2 surface area for Research Use Only (RUO) Cell Expansion Set R17 bioreactor



*Dependent on the number and capacity of flasks
Cell expansion software
Cell expansion software

Customize Your Cell Expansion to Fit Your Needs

Software/System Advancements

Quantum provides system advancements that aid in your compliance efforts.
  • Reporting
  • User authentication
  • Power failure recovery

Installation Qualification and Operational Qualification Services

Leverage our expertise and hands-on device experience to supply audit-quality data for your records.
Terumo Blood and Cell Technologies now provides installation qualification and operational
qualification services for Quantum.


Learn More
Cell expansion bioreactor
Cell expansion bioreactor

Select the Right Cell Expansion Set for Your Work

Versatile options to support scaling from research to clinical.
  • Cell Expansion Set: This preconnected disposable set includes a hollow-fiber bioreactor with a surface
    area of 2.1 m2, gas transfer module, waste bag and harvest bag.
    Depending on the application,
    additional disposable sets and a hardware accessory are available for common process needs.
  • Research Use Only (RUO) Cell Expansion Set R17: Bioreactor contains hollow fibers with a surface area of
    1.7 m2 and is designed for efficient cell expansion in a minimal amount of space.

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