Discover What Quantum Flex Can Do for You

Quantum Flex Cell Expansion System

Solution overview

An automated and functionally closed platform expands a variety of suspension and adherent cell types

Multiple sizes of hollow-fiber bioreactors enable scalable, perfusion-based cell culture

Robust software facilitates fleet and device management and GMP compliance

Where Cells Thrive:
Hollow-Fiber Perfusion Technology

For cell cultured on the Quantum Flex platform, thriving means:

Ready access to fresh media, waste removal and gas exchange over micrometer distances
A robust environment for both suspension and adherent cell culture
Precisely controlled, low-shear expansion
Reduced usage of valuable reagents

Cell Types and Applications Successfully Performed on Quantum Flex

Suspension Cell Expansion

T cells
T-regs
Tumor Infiltrating Lymphocytes (TILs)
CAR-T cells
CD34+ cells

Adherent Cell Expansion

Human pluripotent stem cells (ESCs, iPSCs)
Mesenchymal stem cells (MSCs)
Fibroblasts
Endothelial cells
Neural stem cells (NSCs)

Applications

Viral vector production using adherent and suspension HEK293 cells
Exosome production

Simplify and De-Risk Your Process

Performance varies by user and is dependent on customer processes and materials.

SEE HOW QUANTUM FLEX CAN WORK IN YOUR FACILITY — REQUEST A CONSULTATION.

What if cell culture could harness the power
of perfusion?

Video (1 minute): What if cell culture could harness the power of perfusion as it occurs in the human body? Learn about hollow-fiber perfusion on Quantum Flex.

Demonstration From the Lab: Quantum Flex Cell Expansion System

Video (12 minutes): Visit the lab for a demonstration of key Quantum Flex features and benefits: flexibility, scalability, automation – and it facilitates GMP compliance.

How It Works

Hollow-Fiber Perfusion Bioreactor

Dual loops for microenvironment control

Cell Culture Within the Bioreactor Using Hollow-Fiber Perfusion Technology

For suspension culture, complete media and reagents are gently pumped into both ends of the IC loop; main feeding and gas exchange are achieved via higher flow rate through the EC loop.

For adherent culture, feeding is achieved through low flow rate through the IC loop, while gas exchange is achieved via higher flow rate through the EC loop.

Compare Cell Culture Flasks to Automated Cell Culture

Flasks

Labor-intensive, manual process

Quantum Flex

Automated, customizable process

Possibility of variation between lab personnel and each culture

Reproducible process and a high degree of scalability

Large number of open steps through the process

Functionally closed system from cell loading through harvest

Temperature fluctuations as flasks are moved in and out of the incubator

Continuous control of temperature

Manual pipette process to feed cells and remove waste

Automated perfusion system and customizable control of cell feeding and waste removal

Cell harvest spans hours/days^*

Cells harvested in as little as 20 minutes

^*Dependent on the number and capacity of flasks

Enabling Scalability

Installation Qualification and Operational Qualification Services

Leverage our expertise and hands-on device experience to supply audit-quality data for your records.
Terumo Blood and Cell Technologies now provides installation qualification and operational
qualification services for Quantum Flex.

Learn More