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Quantum Flex Cell Expansion System
Videos Compare Materials Cell Therapy Technologies

Introducing the Next Generation of Cell Expansion

Are you ready for the next generation of cell expansion? Automate the right way, right from the start with the Quantum Flex Cell Expansion System. Gain the flexibility, scalability and connectivity to grow with your therapy, from process development to commercial manufacturing.

Learn More About Quantum Flex

Discover What Quantum Flex Can Do for You

Quantum Flex Cell Expansion System

An automated and functionally closed platform expands a variety of suspension and adherent cell types

Multiple sizes of hollow-fiber bioreactors enable scalable, perfusion-based cell culture

Robust software facilitates fleet and device management and GMP compliance

Where Cells Thrive:
Hollow-Fiber Perfusion Technology

For cell cultured on the Quantum Flex platform, thriving means:

  • Ready access to fresh media, waste removal and gas exchange over micrometer distances
  • A robust environment for both suspension and adherent cell culture
  • Precisely controlled, low-shear expansion
  • Reduced usage of valuable reagents

Cell Types and Applications Successfully Performed on Quantum Flex

Suspension Cell Expansion

  • T cells
  • T-regs
  • Tumor Infiltrating Lymphocytes (TILs)
  • CAR-T cells
  • CD34+ cells

Adherent Cell Expansion

  • Human pluripotent stem cells (ESCs, iPSCs)
  • Mesenchymal stem cells (MSCs)
  • Fibroblasts
  • Endothelial cells
  • Neural stem cells (NSCs)


  • Viral vector production using adherent and suspension HEK293 cells
  • Exosome production

Simplify and De-Risk Your Process

Performance varies by user and is dependent on customer processes and materials.
What if cell culture could harness the power
of perfusion?

Video (1 minute): What if cell culture could harness the power of perfusion as it occurs in the human body? Learn about hollow-fiber perfusion on Quantum Flex.
Demonstration From the Lab: Quantum Flex Cell Expansion System

Video (12 minutes): Visit the lab for a demonstration of key Quantum Flex features and benefits: flexibility, scalability, automation – and it facilitates GMP compliance.

How It Works

Hollow-Fiber Perfusion Bioreactor

Cell Culture Within the Bioreactor Using Hollow-Fiber Perfusion Technology

For suspension culture, complete media and reagents are gently pumped into both ends of the IC loop; main feeding and gas exchange are achieved via higher flow rate through the EC loop.

For adherent culture, feeding is achieved through low flow rate through the IC loop, while gas exchange is achieved via higher flow rate through the EC loop.

Quantum Flex

Compare Cell Culture Flasks to Automated Cell Culture


Labor-intensive, manual process

Quantum system
Quantum Flex

Automated, customizable process

Possibility of variation between lab personnel and each culture

Reproducible process and a high degree of scalability

Large number of open steps through the process

Functionally closed system from cell loading through harvest

Temperature fluctuations as flasks are moved in and out of the incubator

Continuous control of temperature

Manual pipette process to feed cells and remove waste

Automated perfusion system and customizable control of cell feeding and waste removal

Cell harvest spans hours/days*

Cells harvested in as little as 20 minutes

*Dependent on the number and capacity of flasks

Enabling Scalability

Installation Qualification and Operational Qualification Services

Leverage our expertise and hands-on device experience to supply audit-quality data for your records.
Terumo Blood and Cell Technologies now provides installation qualification and operational
qualification services for Quantum Flex.

Learn More

Connectivity to Provide Control and Consistency

The Cell Processing Application (CPA) software works with the device and disposables to provide a holistic, connected solution for cell expansion

  • Protocol builder and management across devices
  • Report management and advanced reporting capabilities
  • Remote monitoring and alarming
  • Flexible deployment configurations
  • Fleet management
  • One to 100 devices connected, with up to 12 users at a time

Mendt M, et al. JCI Insight. 2018;3(8):e99263. Sheu J, et al. Mol Ther Methods Clin Dev. 2015;2:15020. Russell AL, et al. Transfusion. 2018;58(10):2374-2382. Schive SW, et al. CellR4. 2018;6(2):e2519. Haack-Sørensen M, et al. J Transl Med. 2016;14(1):319. Haack-Sørensen M, et al. Scand J Clin Lab Invest. 2018;78(4):293-300. Mennan C, et al. Stem Cell Res Ther. 2019;10(1):99. Mizukami A, et al. Biochem Eng J. 2018;135:36-48. Hanley PJ, et al. Cytotherapy. 2014;16(8):1048-1058. Nankervis B, et al. Curr Stem Cell Rep. 2018;4(1):46-51. Coeshott C, et al. J Transl Med. 2019;17:258. Roberts I, et al. Biotech Lett. 2012;34(12):2307-2315. Paccola Mesquita FC, et al. Stem Cells Int. 2019;2019:9704945. Data on file.

Availability is subject to regulatory clearance


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