Cell Therapy Technologies

Terumo BCT – Cell and Gene Therapy Automation Solutions

Automating your process puts next-generation cell and gene therapies within reach.

Choosing the right automation partner makes all the difference when you need to optimize your process. We offer over 40 years of expertise and a range of modular automated solutions to streamline and simplify the most complex parts of your process. See all products.

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Spectra Optia^®

Apheresis System

The industry-leading cell collection platform that provides an automated and flexible method for collecting MNCs, including monocytes, lymphocytes, CD34+ cells and dendritic cells.

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Integrate automation into your process.

See how adopting automation early in your cell production efforts can help you advance the development of novel therapies for the patients who need them. Maintain the integrity of your work as it progresses into later phases of development by streamlining and simplifying the most complex parts of your process — from cell collections to cell expansion to fill and finish.

Enable reproducible, scalable processes

When comparing mesenchymal stromal cell production in flasks versus the Quantum^® Cell Expansion System, automation showed an 88% reduction in harvest time and labor hours.²
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Increase control over variability

Maintain cell viability of greater than 95% of the inlet cell viability throughout final formulation with the Finia^® Fill and Finish System
Maintain uniformity of cell concentrations to within 5% on all final product bags and a QC bag with Finia.

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Reduce variables in the work path and improve efficiency

Use of an automated bioreactor closed system has been shown to increase yields and reduce growing times for a variety of cell types. In one report, City of Hope generated a GMP-grade lot of clinically viable neural stem cells within nine days with Quantum, compared with six weeks using cell factories.¹

Reduce open events with a closed cell culture environment

The closed environment of the bioreactor remains intact during the cell culture process, eliminating open events and hands-on tasks associated with manual flask-based culture. One study from Baylor College of Medicine Center for Cell and Gene Therapy showed a 99.8% reduction in open events when using Quantum compared to an equivalent flask-based process.²

Expand multiple cell types with Quantum

Mesenchymal stem cells (MSCs)
T cells
Fibroblasts
Dendritic cells
HEK 293

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Performance varies by user and is dependent on customer processes and materials.

You are not in this alone.

We believe that service, support and training go hand in hand with innovation. We have partnered with customers at multiple stages of the development process — from cell collection to cell expansion to final formulation — working together to achieve successful outcomes. Look to Terumo BCT for the following services:

Read the research.

The following institutions have published their findings on the value of Quantum:

City of Hope

GMP Production and Scale-Up of Adherent Neural Stem Cells with a Quantum Cell Expansion System

University of California, Davis

Large-Scale Production of Lentiviral Vector in a Closed System Hollow Fiber Bioreactor

Mayo Clinic

Characterization and Cost-Benefit Analysis of Automated Bioreactor Expanded Mesenchymal Stem Cells for Clinical Applications

Stay informed.

Leverage our 40 years of expertise and broad knowledge to your advantage. Let’s stay in touch.

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On-Demand Webinars

A Lens on the Final Formulation and Fill & Finish Process: Considerations for Process Automation and Device Development
Presented by Kyle Massey, System Engineer at Terumo BCT; Michael Covington, VP and Regulatory CMC at Orchard Therapeutics; and Dalip Sethi, PhD, Senior Scientist at Terumo BCT.
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Real-World Insights Into Automated Solutions for Cell and Gene Therapy Bioprocessing
Featuring perspectives from Bruce Levine, PhD, Director of the Cell and Vaccine Production Facility (CVPF), University of Pennsylvania, and Gerhard Bauer, Laboratory Director, GMP Facility, UC Davis Institute for Regenerative Cures; moderated by Jim Beltzer, PhD, from Terumo BCT.
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Clinical Application of Adipose-Derived Stromal Cells in Ischemic Heart Disease
Presented by Mandana Haack-Sørensen, MSc, PhD, Director of Manufacturing, Cell2Cure; Jens Kastrup, MD, DMSc, Chief Physician, Department of Cardiology, The Heart Centre, Rigshospitalet, Denmark.
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Serendipity – To Find a Process While Looking for a Product
Presented by Stefano Baila, Director of Operations at Anemocyte
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¹Data from one report: Tirughana R, Metz MZ, Li Z, et al. GMP production and scale-up of adherent stem cells with a Quantum Cell Expansion System. Mol Ther Methods Clin Dev. 2018;10:48-56.

²Hanley P, Mei Z, Durett A, et al. Efficient manufacturing of therapeutic mesenchymal stromal cells with the use of the Quantum Cell Expansion System. Cytotherapy. 2014;16(8):1048-1058.

COBE^® 2991 CELL PROCESSOR

The industry standard for a variety of cell processing applications that has earned its reputation for reliability, ease of use, instrument consistency, disposable set performance and multiapplication flexibility.

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QUANTUM^®

CELL EXPANSION SYSTEM

An automated cell culture platform that has been proven effective in the consistent expansion of a variety of cell types and genes, including suspension cells, adherent cells, viral vectors and exosomes.

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QUANTUM^®

CELL EXPANSION SYSTEM

QUANTUM^®

CELL EXPANSION SYSTEM

QUANTUM^®

CELL EXPANSION SYSTEM

BIOPROCESSING WELDERS

Dependable sterile connection devices to support final product quality and operational efficiency throughout your process.

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DATA MANAGEMENT

Workflow-centered software that connects your cell transplant/cell therapy teams and systems across the patient pathway and centrally manages patient, product and process data.

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CELL PROCESSING SYSTEM

Currently under development.

FINIA^®

FILL AND FINISH SYSTEM

The first device of its kind to automate final formulation and the fill and finish step. Finia is designed to automatically formulate, aliquot, cool and package cell and gene therapy products to enable cryopreservation.

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Choosing the right automation partner makes all the difference when you need to optimize your process. We offer over 40 years of expertise and a range of modular automated solutions to streamline and simplify the most complex parts of your process. See all products.

Spectra Optia®

Apheresis System

Integrate automation into your process.

Enable reproducible, scalable processes

Increase control over variability

Reduce variables in the work path and improve efficiency

Reduce open events with a closed cell culture environment

You are not in this alone.

Read the research.

The following institutions have published their findings on the value of Quantum:

City of Hope

GMP Production and Scale-Up of Adherent Neural Stem Cells with a Quantum Cell Expansion System

University of California, Davis

Large-Scale Production of Lentiviral Vector in a Closed System Hollow Fiber Bioreactor

Mayo Clinic

Characterization and Cost-Benefit Analysis of Automated Bioreactor Expanded Mesenchymal Stem Cells for Clinical Applications

Stay informed.

Leverage our 40 years of expertise and broad knowledge to your advantage. Let’s stay in touch.

News

On-Demand Webinars

COBE® 2991 CELL PROCESSOR

QUANTUM®

CELL EXPANSION SYSTEM

QUANTUM®

CELL EXPANSION SYSTEM

QUANTUM®

CELL EXPANSION SYSTEM

QUANTUM®

CELL EXPANSION SYSTEM

BIOPROCESSING WELDERS

DATA MANAGEMENT

CELL PROCESSING SYSTEM

FINIA®

FILL AND FINISH SYSTEM

Spectra Optia^®

COBE^® 2991 CELL PROCESSOR

QUANTUM^®

QUANTUM^®

QUANTUM^®

QUANTUM^®

FINIA^®