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COBE® 2991
Cell Processor
Overview How It Works Step by Step Protocols Disposables Specifications

Showcasing Versatility

From time-tested deglycerolization procedures to bone marrow processing, the COBE 2991 cell processor has been a solid solution for a variety of procedures for washing and concentrating cellular components. Beyond the list of Terumo BCT-validated protocols, customers continue to establish new uses for the device.

Improving the Process

The COBE 2991 cell processor offers an alternative to labor-intensive methods for the separation of cell products, such as manually layering blood over a density gradient separation medium using conical tubes. These methods involve a large number of operator steps and manual pipetting techniques that require significant practice, introducing variability and the opportunity for operator error. Automated processing puts control at the user's fingertips. Protocols can be easily programmed for efficient, reproducible results while saving time and reducing the number of manual operating steps. For maximum flexibility, nearly all aspects of operation can be controlled manually. Intuitive operation saves training time, requires little technical support and reduces the opportunity for operator errors.

Simplifying With Color-Coded Tubing

The color-coded tubing on cell processing disposable sets used with the COBE 2991 cell processor enables you to easily follow a flow path, facilitating quick loading. Specialty disposable sets for bone marrow processing and other procedures allow concentration, density gradient separation and cell washing with a single disposable set.

The COBE 2991 cell processor has been used for these applications:
Deglycerolization of previously frozen products
Production of bone marrow concentrates
Washing of mononuclear cells and stem cell concentrate
Washing of blood salvaged during surgery for autologous reinfusion
Volume reduction of cultured and expanded cell products
Cell concentration and media exchange
Density gradient separation
Washing of packed red blood cells to remove plasma

Watch a cell processing procedure from start to finish

How It Works

The key features of the COBE 2991 cell processor are its centrifuge and its flexible diaphragm. When the centrifuge is spinning, the flexible diaphragm located inside the centrifuge bowl can be inflated with hydraulic fluid. As the flexible diaphragm inflates, it presses against the bottom of the cell processing bag. This gives the COBE 2991 cell processor the ability to express fluids and/or cells for removal or collection during centrifugation. The clear centrifuge cover allows you to visually observe cell separation and fluid expression.


Rotating seal

Allows the cell processing bag to rotate while the centrifuge is spinning and provides a pathway for fluid to be removed and/or added during processing.


Red cell detector (RCD)

An optical sensor that uses infrared light to detect the presence of red blood cells (RBCs) in fluids expressed at certain times during cell processing. Allows the cell processing bag to rotate while the centrifuge is spinning and provides a pathway for fluid to be removed and/or added during processing.


Flexible diaphragm

Inflates when hydraulic fluid is pumped underneath it. When inflated, it pushes against the bottom of the cell processing bag, causing cells or supernatant to be expressed.

Take It Step-by-step

Follow these basic steps for almost all cell processing procedures.

46 cm/18 in
77 cm/30 in
Counter height
96 cm/37.5 in
Top of control box
155 cm/61 in
195 kg/430 lb
Heat output
479 kcal/hr
1,900 BTU/hr
Air flow
70 CFM (2 m3)
See operating clearance.
Operating clearance
A minimum of 38 cm (15 in) is required on either the right or the left side. A 5.1 cm (2 in) clearance must be maintained at the rear for air circulation. Clearance at the front is 76 cm (30 in).
Service clearance
A minimum of 76 cm (30 in) is required on all sides for service. Device is equipped with fixed casters in the rear and swivel casters in the front to permit moving the machine for servicing. Casters have a locking device to prevent movement during operation.


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