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Quantum® Cell Expansion System - How It Works

Product Confidence. Process Scalability.

The Quantum system is an automated cell culture platform that can help simplify the open, labor-intensive manual tasks associated with flask-based culture, helping improve the reproducibility and scalability of your cell culture process to meet your overall manufacturing requirements.

Below is a video and list of features, which explain how the Quantum system works.

INCUBATOR + BIOSAFETY CABINET + CLEAN ROOM = The QUANTUM system

The Quantum system is able to replace
an incubator, biosafety cabinet and
clean room typically used for
flask-based culture.

Within a very small footprint of only 0.3 m2, the Quantum system can replace the need for an incubator, biosafety cabinet and clean room typically required for flask-based culture. In addition, it can reduce the need for these workstations during cell culture by providing a functionally closed system with temperature and gas control.

CELL HARVEST IN AS FEW AS 20 MINUTES

The harvest process is controlled by using the intuitive touch screen user interface on the Quantum system.

When working with the number of flasks required to expand clinically relevant cell volumes, manual cell culture methods require a labor-intensive harvest procedure that can take days to complete. To expedite the process, the Quantum system features a hollow-fiber bioreactor with an intra- and extra-capillary flow path that completes a full harvest procedure in as few as 20 minutes. Harvested cells can be captured in a 0.5 L bag that can be sterilely sealed for downstream processing.

120 T-175 FLASKS = ONE BIOREACTOR

A close up of the hollow fibers within the Quantum system’s bioreactor.

The 3D bioreactor used with the Quantum system contains about 11,500 hollow fibers, providing a 2.1 m2 cell culture surface area, which is equivalent to the surface area of 120 T-175 flasks. The bioreactor’s compact design allows a substantial amount of surface area in a minimal amount of space. This effective use of lab space results in facility, storage and workflow savings.

FOUR EASY STEPS

The Quantum system’s four easy steps can all be controlled by a suite of pre-defined tasks.

The Quantum system transforms open, labor-intensive manual cell culture processes into a closed, automated and reproducible process that includes four primary phases. First, the Quantum system is primed as the nutrients, metabolites and gases diffuse across the fibers in the bioreactor. Second, cells are loaded into the bioreactor. Third, media exchange begins with the continuous control of temperature, cell feeding and waste removal. Finally, cells are harvested in as few as 20 minutes.

40 percent REDUCTION IN COSTS, 70 percent REDUCTION IN LABOR

A skilled operator can manage up to 10 Quantum systems.

By consolidating workstations and using a sophisticated touch screen user interface, it is now possible for a skilled operator to manage up to 10 Quantum systems at once. This improvement in workflow efficiency not only saves space, but has also been shown to provide product benefits, including less media, larger cell yields, shorter processing times, up to a 70 percent reduction in labor and up to 40 percent reduction in cost.

MAINTAINS CELL CHARACTERISTICS CONSISTENT WITH FLASKS

A 100X magnification of morphology of cells cultured in the Quantum system.

The National Institutes of Health (NIH) analyzed Bone Marrow Stromal Cells (BMSCs) from the Quantum system to determine if they retained their differentiation potential, resulting in three major findings. First, cell yields in all test cases were higher when cells were grown in the Quantum system compared to Cell Factories. Second, BMSCs grown in the Quantum system were found to have similar phenotypes compared to BMSCs grown in Cell Factories. Lastly, BMSCs from both the Quantum system and Cell Factories are able to differentiate into adipocytes.The study concluded that growth in the Quantum system does not alter the differentiation potential of the subset of stem cells within the BMSC population.

HYPOXIC AND NORMOXIC CONDITIONS

The direct gas connector facilitates control of the cell culture environment.

A direct gas connection allows operators to control the cell culture environment, enabling any gas blend connection to the Quantum system. An internal investigation demonstrated that hypoxic and normoxic conditions have no significant difference on cell yield, viability, phenotypic, morphologic or differentiation potential.


Software

Now the Quantum system goes beyond automating your cell culture process, with new system advancements that aid in your compliance efforts. New features work to help address the increasing importance of current good manufacturing practices (cGMPs) and activities associated with Part 11 compliance.


 

Introducing Four New Features


Reporting

Automate your manual recording with electronic data capture for each step of your cell culture process. From loading the system through harves​t, you can now easily view, download or run various detailed reports for each task performed.



Remote alarms

Keeps you informed with customizable, remote alarm notifications. Whether you are down the hall or across town, you will know what happened and be able to decide if you need to return to the lab.



User authentication

Provide greater control of your process, tracking tasks and configuration changes performed by operators and administrators for improved traceability.



Power failure recovery

Restores the system to the previously running state. Whether the power was down for seconds or minutes, the previous system task is restored and reports are updated.



For more information on cGMPs and activities associated with Part 11 compliance, please refer to the FDA Code of Federal Regulations Title 21.​


​​​*Customers are responsible for validating the use of the Quantum system to expand cells for their intended therapy.​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​

 

Learn More

 Overview
 Technical Resources
 Manual versus Automated Comparison Video
 Research



​​​*Customers are responsible for validating the use of the Quantum system to expand cells for their intended therapy.​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​

The Quantum system can be used in the production process of the following therapies:*

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