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COBE® 2991 Cell Processor

​Introduced more than 30 years ago, the ​COBE 2991 Cell Processor has set the industry standard as a reliable laboratory tool for a variety of cell processing applications. It earned its enviable reputation ​for reliability, ease of use, instrument consistency, disposable set performance and multi-application flexibility thanks to its many devoted users.

Showcasing Versatility

From time-tested deglycerolization procedures to bone marrow processing, the COBE 2991 Cell Processor has been a solid solution for a variety of procedures for washing and concentrating cellular components. Beyond the list of Terumo BCT-validated protocols, customers continue to establish new uses for the device.


  • Deglycerolization of previously frozen products
  • Produce bone marrow concentrates
  • Washing of mononuclear cell (MNC) and stem cell concentrate
  • Washing of blood salvaged during surgery for autologous reinfusion
  • Volume reduction of cultured and expanded cell products
  • Cell concentration and media exchange
  • Density gradient separation
  • Washing of packed red blood cells to remove plasma
 LEARN MORE: View Terumo BCT-validated protocols

Improving the Process

The COBE 2991 Cell Processor offers an alternative to labor-intensive methods for the separation of cell products, such as manually layering blood over a density gradient separation medium using conical tubes. These methods involve a large number of operator steps and manual pipetting techniques that require significant practice, introducing variability and the opportunity for operator error.

Automated processing puts control at the user’s fingertips. Protocols can be easily programmed for efficient, reproducible results, while saving time and reducing the number of manual operating steps. For maximum flexibility, nearly all aspects of operation can be controlled manually. Intuitive operation saves training time, requires little technical support and reduces opportunity for operator errors.

 LEARN MORE: Watch a cell processing procedure from start to finish

Simplifying with Color-Coded Tubing

The color-coded tubing on the cell processing disposable sets used with the COBE 2991 Cell Processor enable you to follow a flow path easily, facilitating quick loading. Specialty disposable sets for bone marrow processing and other procedures allow concentration, density gradient separation and cell washing with a single disposable set.

 LEARN MORE: Check out the cell processing disposable sets

Request more information on the COBE 2991 Cell Processor


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