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Plasma Exchange
A Clear Road to Results for MG and GBS Patients
Overview MG GBS How It Works Safety Resources References

How It Works

Plasma exchange is a well established immunomodulatory therapy which rapidly removes disease mediators and circulating immune complexes to relieve GBS and MG symptoms. (Saperstein and Barohn, 2004)
Physicians can quantify and measure known disease mediators before plasma exchange as well as after in order to inform the next phase of treatment providing immediate objective results. (Derksen, 1984)

Reeves HM, Winters JL. The mechanisms of action of plasma exchange. Br J Haematol. 2014;164(3);342-351.

Plasma Exchange Rapidly Reduces Disease Mediators

(Guptil et al., 2016)
(Guptil et al., 2016)

Plasma Exchange on the Spectra Optia® Apheresis System:

  • Provides automated monitoring and allows for the maintenance of fluid balance
  • Efficiently removes targeted components and achieves highly predictable results with the patented Automated Interface Management (AIM) system
  • Has a plasma removal efficiency up to 87 percent (Tormey, 2010)
  • Can be performed via peripheral or central vascular access and as an outpatient or inpatient treatment
Learn More

Hear From Your Peers

See how one physician uses the Spectra Optia system’s plasma exchange therapy using peripheral access on an outpatient basis.

Plasma Exchange: An Established and Growing Treatment Area

Safety Information


  • No known contraindications for the system's use, except for those associated with all automated apheresis systems
  • The infusion of certain solutions and replacement fluids may be contraindicated in some patients

Possible patient reactions

  • Anxiety, headache, light-headedness, digital and/or facial paresthesia, fever, chills, hematoma, hyperventilation, nausea and vomiting, syncope (fainting), urticaria, hypotension and allergic reactions

Reactions to transfused blood products can include1

  • Fever, circulatory overload, shock, allergic reactions, alloimmunization, graft-versus-host disease and transmission of infection

Restricted to prescription use only

  • Operators must be familiar with the system's operating instructions
  • Procedures must be performed by qualified medical personnel
  • A supervisory practitioner may supervise from a physician office or other nonhospital space that is not officially part of the hospital campus as long as he or she remains immediately available2

1AABB (ed.), et al., Circular of Information for the Use of Human Blood and Blood Components. 2006, tenth edition, Council of Europe Publishing, Seattle, WA.

2American Society for Apheresis. Guidelines for therapeutic apheresis clinical privileges. J Clin Apher. 2007;22(3):181-182.

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International Content. Approved labeling, indications and instructions may vary by country. Reference the Instructions for Use labeling for a complete listing of indications, warnings and precautions.

The Immunomodulatory Effect of Plasma Exchange


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