SPD Training

Spectra Optia SPD procedure with a Column – Demonstration Videos

These videos demonstrate an operator moving through the various stages of an SPD Procedure using a Column.

Connect a column to the Exchange Disposable Tubing Set and attach a waste bag for priming the column and prime divert.

Prime a column using the Spectra Optia system.

Connecting the Treated Plasma Bag and priming prior to starting the procedure.

Spike the treated plasma bag and connect it to the outlet end of a column. Prime the inlet and return lines prior to the patient connection.

Diverting Prime Saline

Divert the prime saline used to prime the column at the start of the SPD procedure. Prime Divert will only occur if selected as an option prior to the procedure.

Completing Prime Divert & Filling the Treated Plasma Bag

Complete the Prime Divert and fill the treated plasma bag prior to returning treated plasma to the patient.

Rinsing the Column

Enter the data and return the patient’s plasma in the column prior to completing rinseback.

Returning plasma in Treated Plasma Bag and Rinseback

Return the plasma in the treated plasma bag prior to completing rinseback.

Operator’s Manual Information

Spectra Optia Apheresis System

Intended Use

The Spectra Optia Apheresis System, a blood component separator, may be used to perform the following therapeutic apheresis, cell collection, and cell processing procedures^*:

Therapeutic plasma exchange
Therapeutic plasma exchange with a secondary plasma device
Red blood cell exchange, depletion, and depletion/exchange
Mononuclear cell collection from the peripheral blood
Granulocyte collection from the peripheral blood
White blood cell depletion
Platelet depletion
Processing of harvested bone marrow

^*Procedure availability varies by country.

Contraindications for Use

Leukocytapheresis is contraindicated in AML FAB M3 (APL) because of the accompanying disseminated intravascular coagulation. (Vahdat L, et al., “Early mortality and the retinoic acid syndrome in acute promyelocytic leukemia: impact of leukocytosis, low-dose chemotherapy, PMN/RAR-alpha isoform and CD13 expression in patients treated with all-trans retinoic acid.” Blood 1994; 84: 3843-3849. Daver, et al., “Clinical characteristics and outcomes in patients with acute promyelocytic leukaemia and hyperleucocytosis.” British Journal of Haematology 2015, 168, 646-653.)
Other contraindications for the use of the Spectra Optia system are limited to those associated with the infusion of solutions and replacement fluids as required by the apheresis procedure, and those associated with all types of automated apheresis systems.

Possible adverse events of apheresis procedures include:

Anxiety, headache, light-headedness, digital and/or facial paresthesia, fever, chills, hematoma, hyperventilation, nausea and vomiting, syncope (fainting), urticaria, hypotension, allergic reactions, infection, hemolysis, thrombosis in patient and device, hypocalcemia, hypokalemia, thrombocytopenia, hypoalbuminemia, anemia, coagulopathy, fatigue, hypomagnesemia, hypogammaglobulinemia, adverse tissue reaction, device failure/disposable failure, air embolism, blood loss/anemia, electrical shock hazard, fluid imbalance, inadequate separation of blood components.

Reactions to Blood Products Transfused During Procedures

Reactions to transfused blood products can include fever, circulatory overload, shock, allergic reactions, alloimmunization, transfusion-related acute lung injury (TRALI), and graft-versus-host disease (GVHD), as well as transmission of infectious diseases and bacteria. (Sources: Circular of Information for the Use of Human Blood and Blood Components, AABB, et al, ed., April, 2006; Guide to the preparation, use and quality assurance of blood components, 10th Edition, Council of Europe Publishing; Blood. Toy P et al., “Transfusion-Related Acute Lung Injury: Incidence and Risk Factors.” Blood, 2012; 119: 1757-1767.)

Restricted to prescription use only:

Operators must be familiar with the system's operating instructions.
Procedures must be performed by qualified medical personnel.

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