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Case Studies: Scaling Cell Therapy Manufacturing

Gain insights into T-cell expansion, viral vector production and scaling production of mesenchymal stem cells (MSCs) through the use of a functionally closed, automated cell culture process.

Dr. Beltzer presents several case studies describing how process development and economic goals were achieved in industry and academic settings. Results include a 500-fold expansion of T-cells in 12 days, 40 percent reduction in cost of goods (COGs) of growing cells for an allogeneic cell therapy and automated viral vector production with titers similar to flask-based processes. Particular attention will be directed toward the process changes often needed to meet these goals.

In this webinar, you will:

  • See the results of T-cell expansion using a hollow-fiber bioreactor system
  • Learn techniques for scaling production of MSCs
  • Discover a new approach to viral vector production
  • Hear about a case study on achieved cost and labor savings

About The Presenter:

Jim Beltzer, PhD

Senior Cell Processing Specialist, Terumo BCT (Colorado, U.S.)

Jim earned his PhD in biochemistry at Purdue University and completed his post-doctoral fellowship at the Biocenter in Basel, Switzerland. He worked at several start-up biotechnology companies in the Boston area and at Corning Life Sciences prior to joining the cell processing team at Terumo BCT. He has more than 25 years of research and development experience in a broad range of disciplines.


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